Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP‐1) have previously been linked to cell differentiation and pattern formation during development through a proposed role in the activation of latent growth factors of the TGF‐β superfamily. Recent finding(1) indicate that BMP‐1 is identical to pro‐collagen C‐proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation. This observation suggests that a functional link may exist between astacin metalloproteinases, growth factors and cell differentiation and pattern (...) formation during development. Taken together, current studies indicate that BMP‐1 and possibly other astacin metalloproteinases are multifunctional enzymes that act directly on growth factors and the ECM. In combination, these dual actions would have profound effects on developmental processes. (shrink)

The body wall of Hydra is organized as an epithelial bilayer with an intervening extracellular matrix (ECM). Molecular and biochemical analyses of Hydra ECM have established that it contains components similar to those seen in more complicated vertebrates such as human. In terms of biophysical parameters, Hydra ECM is highly flexible; a property that facilitates continuous movements along the organism's longitudinal and radial axis. A more rigid ECM, as in vertebrates, would not be compatible with this degree of movement. The (...) flexible nature of Hydra ECM can now be explained in part by the unique structure of the organism's collagens. Interestingly, some aspects of the structural features of Hydra collagens mimic what is seen in Ehlers‐Danlos syndrome, an inherited condition in humans that results in an abnormally flexible ECM that can be debilitating in extreme cases. This review will focus on structure–function relationships of the ECM of Hydra. BioEssays 23:716–724, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

What is truth? Michael Lynch defends a bold new answer to this question. Traditional theories of truth hold that truth has only a single uniform nature. All truths are true in the same way. More recent deflationary theories claim that truth has no nature at all; the concept of truth is of no real philosophical importance. In this concise and clearly written book, Lynch argues that we should reject both these extremes and hold that truth is a functional property. (...) To understand truth we must understand what it does, its function in our cognitive economy. Once we understand that, we'll see that this function can be performed in more than one way. And that in turn opens the door to an appealing pluralism: beliefs about the concrete physical world needn't be true in the same way as our thoughts about matters -- like morality -- where the human stain is deepest. (shrink)

In this engaging and spirited text, Michael Lynch argues that truth does matter, in both our personal and political lives. He explains that the growing cynicism over truth stems in large part from our confusion over what truth is.

In Natural Rights and the New Republicanism, Michael Zuckert proposes a new view of the political philosophy that lay behind the founding of the United States.

Know-it-All Society is about how we form and maintain our political convictions, and the ways in which political ideologies, human psychology and technology conspire to make our society more dogmatic, less intellectually humble and ultimately less democratic.

An investigation into the way in which information technology has shaped how and what we know, from "Google-knowing" to privacy and social media.

Leo Strauss and his alleged political influence regarding the Iraq War have in recent years been the subject of significant media attention, including stories in the _Wall Street Journal _and _New York Times._ _Time_ magazine even called him “one of the most influential men in American politics.” With _The Truth about Leo Strauss_, Michael and Catherine Zuckert challenged the many claims and speculations about this notoriously complex thinker. Now, with _Leo Strauss and the Problem of Political Philosophy_, they turn (...) their attention to a searching and more comprehensive interpretation of Strauss’s thought as a whole, using the many manifestations of the “problem of political philosophy” as their touchstone. For Strauss, political philosophy presented a “problem” to which there have been a variety of solutions proposed over the course of Western history. Strauss’s work, they show, revolved around recovering—and restoring—political philosophy to its original Socratic form. Since positivism and historicism represented two intellectual currents that undermined the possibility of a Socratic political philosophy, the first part of the book is devoted to Strauss’s critique of these two positions. Then, the authors explore Strauss’s interpretation of the history of philosophy and both ancient and modern canonical political philosophers, including Plato, Aristotle, Machiavelli, and Locke. Strauss’s often-unconventional readings of these philosophers, they argue, pointed to solutions to the problem of political philosophy. Finally, the authors examine Strauss’s thought in the context of the twentieth century, when his chief interlocutors were Schmitt, Husserl, Heidegger, and Nietzsche. The most penetrating and capacious treatment of the political philosophy of this complex and often misunderstood thinker, from his early years to his last works, _Leo Strauss and the Problem of Political Philosophy_ reveals Strauss’s writings as an attempt to show that the distinctive characteristics of ancient and modern thought derive from different modes of solving the problem of political philosophy and reveal why he considered the ancient solution both philosophically and politically superior. (shrink)

A Choice Outstanding Academic Title for 1999 Academic debates about pluralism and truth have become increasingly polarized in recent years. One side embraces extreme relativism, deeming any talk of objective truth as philosophically naïve. The opposition, frequently arguing that any sort of relativism leads to nihilism, insists on an objective notion of truth according to which there is only one true story of the world. Both sides agree that there is no middle path. In Truth in Context, Michael Lynch (...) argues that there is a middle path, one where metaphysical pluralism is consistent with a robust realism about truth. Drawing on the work of Hilary Putnam, W.V.O. Quine, and Ludwig Wittgenstein, among others, Lynch develops an original version of metaphysical pluralism, which he calls relativistic Kantianism. He argues that one can take facts and propositions as relative without implying that our ordinary concept of truth is a relative, epistemic, or "soft" concept. The truths may be relative, but our concept of truth need not be. (shrink)

These essays center around two questions: Does truth have an underlying nature? And if so, what sort of nature does it have?

Pluralism about truth is the view that there is more than one way for a proposition to be true. When taken to imply that there is more than one concept and property of truth, this position faces a number of troubling objections. I argue that we can overcome these objections, and yet retain pluralism's key insight, by taking truth to be a multiply realizable property of propositions.

Evidence-based medicine has always required integration of patient values with ‘best’ clinical evidence. It is widely recognized that scientific practices and discoveries, including those of EBM, are value-laden. But to date, the science of EBM has focused primarily on methods for reducing bias in the evidence, while the role of values in the different aspects of the EBM process has been almost completely ignored.

The Western world is currently gripped by an obsessive concern for the rights of animals - their uses and abuses. In this book, Leahy argues that this is a movement based upon a series of fundamental misconceptions about the basic nature of animals. This is a radical philosophical questioning of prevailing views on animal rights, which credit animals with a self-consciousness like ours. Leahy's conclusions have implications for issues such as bloodsports, meat eating and fur trading.

Minimalists generally see themselves as engaged in a descriptive project. They maintain that they can explain everything we want to say about truth without appealing to anything other than the T-schema, i.e., the idea that the proposition that p is true iff p. I argue that despite recent claims to the contrary, minimalists cannot explain one important belief many people have about truth, namely, that truth is good. If that is so, then minimalism, and possibly deflationism as a whole, must (...) be rejected or recast as a profoundly revisionary project. (shrink)

Corporate social responsibility has been intensively discussed in business ethics literature, whereas the social responsibility of private consumers appears to be less researched. However, there is also a growing interest from business ethicists and other scholars in the field of consumer social responsibility. Nevertheless, previous discussions of ConSR reveal the need for a viable conceptual basis for understanding the social responsibility of consumers in an increasingly globalized market economy. Moreover, evolutionary aspects of human morality seem to have been neglected despite (...) the fact that private consumers are undoubtedly human beings. In addition to that, empirical studies suggest that many consumers believe themselves to be responsible but do not act according to their alleged values or attitudes. This raises the question of what deters them from doing so. Therefore, the contribution of this conceptual paper is threefold: we conceptualize ConSR in terms of a combination of a Max Weber-inspired approach with the social connection approach to shared responsibility proposed by Iris Marion Young; shed light on the previously neglected implications of an evolutionarily induced bounded morality for ConSR, and identify potential obstacles to socially responsible consumption, particularly against the backdrop of shared social responsibility and bounded morality. In this latter respect, the paper focuses specifically on the obstacles of low moral intensity, moral stupefaction, informational complexity, and the lack of perceived consumer effectiveness. In sum, the paper advances knowledge in the field of ConSR by using a transdisciplinary, literature-based approach. (shrink)

This paper contributes to the (re-)conceptualisation of responsible innovation by proposing an evolutionary economic approach that focuses on the role of consumers in the innovation process. After a discussion of the philosophical foundations and ethical implications of this approach, which bears an explanatory potential that has not been adequately considered in previous discussions of responsible innovation, we present a first step towards capturing the important but often neglected role of consumers in innovation processes (including responsible innovation): We propose an agent-based (...) model that incorporates a multidimensional space of characteristics in which new products or services are represented by more than the mere aspect of price and quality. Instead, innovations are denoted by a large set of characteristics, including also negative or harmful ones. The model is used to illustrate that consumers’ heterogeneity and bounded rationality – even if considered in a simple manner – indeed play a crucial role in the creation and diffusion of responsible innovation which can and should be used for further work in this field and for possible extensions of the model. (shrink)

In this paper, I raise two questions about epistemic commitments, and thus, indirectly, about our epistemic agency. Can we rationally defend such commitments when challenged to do so? And if so, how?

Jonah N. Schupbach and Jan Sprenger and Vincenzo Crupi and Katya Tentori have recently proposed measures of explanatory power and have shown that they are characterized by certain arguably desirable conditions or axioms. I further examine the properties of these two measures, and a third measure considered by I. J. Good and Timothy McGrew . This third measure also has an axiomatic representation. I consider a simple coin-tossing example in which only the Crupi–Tentori measure does not perform well. The Schupbach–Sprenger (...) and Good–McGrew measures are based on different notions of explanatory power, but both are tenable. 1 Introduction2 Measures of Explanatory Power3 The Schupbach–Sprenger Measure4 The Crupi–Tentori Measure5 The Good–McGrew Measure6 Affirmative versus Comprehensive Explanatory Power7 Coin-Flipping Examples8 Decomposition9 Conclusion. (shrink)

According to alethic functionalism, truth is a higher-order multiply realizable property of propositions. After briefly presenting the views main principles and motivations, I defend alethic functionalism from recent criticisms raised against it by Cory Wright. Wright argues that alethic functionalism will collapse either into deflationism or into a view that takes true as simply ambiguous. I reject both claims.

Beginning in earnest in the late 1990s, educational researchers devoted increasing attention to the study of “active learning,” leading to a robust literature on the topic in the scholarship of teaching and learning. Meanwhile, during largely the same period, political theorists discovered the radical philosophy of Giorgio Agamben, which soon after began to ripple through more radical forms of philosophy of education. While both the SoTL works on active learning and writings of “Agambenian” philosophers of education have offered new insights (...) into their respective fields, active learning has not yet received a systematic philosophical reflection and the community of Agambenian philosophy of education has not yet been systematized. This article addresses both gaps, first through an outline of existing Agambenian approaches to the philosophy of education and second by theorizing active learning as a form of “destituent potential.” The systematic reflection on the three threads of Agambenian philosophy of education—whatever, potentiality, and study—offers an introduction to less familiar readers, and the second section offers a model for how philosophical concepts can become theoretical tools for SoTL analysis. (shrink)

Like William James before him, Huw Price has influentially argued that truth has a normative role to play in our thought and talk. I agree. But Price also thinks that we should regard truth-conceived of as property of our beliefs-as something like a metaphysical myth. Here I disagree. In this paper, I argue that reflection on truth's values pushes us in a slightly different direction, one that opens the door to certain metaphysical possibilities that even a Pricean pragmatist can love.

Philosophers often distinguish in some way between two senses of life's meaning. Paul Edwards terms these a ‘cosmic’ and ‘terrestrial’ sense. The cosmic sense is that of an overall purpose of which our lives are a part and in terms of which our lives must be understood and our purposes and interests arranged. This overall purpose is often identified with God's divine scheme, but the two need not necessarily be equated. The terrestrial sense of meaning is the meaning people find (...) in their own lives apart from the place of their lives in any ultimate end or context. (shrink)

Accounts of leadership in relation to ethics can and do go wrong in several ways that may lead us too quickly into thinking there is a tighter relationship between ethics and leadership than we have reason to believe. Firstly, these accounts can be misled by the centrality of values talk in recent discussions of leadership into thinking that values of a particular kind are sufficient for leadership. Secondly, the focus on character in recent leadership accounts can lead to a similar (...) error. The assumption here is that because good character is often a locus of descriptions of leaders, such character is necessary and sufficient for leadership. Thirdly, we can fall victim to an observer bias that colors our accounts of the leaders we admire and thus wish to either have or be, which in turn leads to the fourth way in which accounts of leadership can go wrong in their description of the role of ethics in leadership. Through inattention or through wishful thinking accounts of leadership can become merely prescriptive and stipulate that ethics is requisite and at least partly constitutive of leadership. Keeping in mind these ways in which accounts of leadership commonly go astray, we can say that any adequate account of leadership must, at least in the first instance, be able to differentiate not only between leadership and good ethical character, but also between leadership and power, authority, influence, managerial ability, and charisma. Taking a closer look at some of the ways that the relation between leadership and ethics is misconstrued is necessary to better understanding both leadership and its connection to ethics. It is, however, just a first step. Asking whether we have reason to think of leadership as an Aristotelian virtue should, we think, enable us to give a more accurate and useful account of the complexity of the relation. It also captures underlying reasons for wanting to see the two as intrinsically connected. (shrink)

Are most people sincere when they share misinformation and conspiracies online? This question, while natural and important, is difficult to answer for obvious reasons. But it also applies poorly to one of the main vehicles for misinformation—memes. And it can be ambiguous; as a result, we should be mindful of two distinctions. First, a distinction between belief and a related propositional attitude, commitment. And second, the distinction between the propositional content of an attitude and what I will call its political (...) meaning. I will suggest that these distinctions not only can help us understand how we communicate online, but they also suggest a lesson about what we should be focusing on when fighting misinformation. (shrink)

Supervenience has provided a way for nonreductive materialists to explain how the mental can be physically irreducible but still physically respectable. In recent years, doubts about this research program have emerged from a number of quarters. Consequently, Terence Horgan has argued that nonreductive materialists must appeal to an upgraded "superdupervenience," if supervenience is to do any materialist work. We argue that nonreductive materialism cannot meet this challenge. Superdupervenience is impossible.

This philosophical analysis of the phenomenon of racism brings together some of the most influential analytic philosophers writing on racism today. The introduction by Tamas Pataki outlines the historical and thematic development of conceptions of race and racism, and locates the following essays against the backdrop of contemporary reactions to that development. While the framework is primarily analytic, the volume also includes essays deeply informed by psychoanalysis, phenomenology, and feminist and social theory. The fourteen chapters in this collection address three (...) interrelated questions: What is racism? What are the causes of racism? and What are the moral and political implications of racism? Although their approaches are wide ranging, the contributors to Racism in Mind broadly endorse a psychological-characterological approach to the understanding of many aspects of racism. (shrink)